Unveiling of a messenger: Gut microbes make a neuroactive signal.
editorial · Level V
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- Record sourced from PubMed, PMID 38848674.
- Also identified by DOI 10.1016/j.cell.2024.05.014 and PMC identifier 11890971.
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Abstract
Gut microbes are known to impact host physiology in several ways. However, key molecular players in host-commensal interactions remain to be uncovered. In this issue of Cell, McCurry et al. reveal that gut bacteria perform 21-dehydroxylation to convert abundant biliary corticoids to neurosteroids using readily available H<sub>2</sub> in their environment.
Medical subject headings
- Gastrointestinal Microbiome