LDL receptor in alphavirus entry: structural analysis and implications for antiviral therapy.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 38851803.
- Also identified by DOI 10.1038/s41467-024-49301-1 and PMC identifier 11162471.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
Various low-density lipoprotein receptors (LPRs) have been identified as entry factors for alphaviruses, and structures of the corresponding virion-receptor complexes have been determined. Here, we analyze the similarities and differences in the receptor binding modes of multiple alphaviruses to understand their ability to infect a wide range of hosts. We further discuss the challenges associated with the development of broad-spectrum treatment strategies against a diverse range of alphaviruses.
Medical subject headings
- Alphavirus
- Antiviral Agents
- Receptors, LDL
- Virus Internalization