Comparison of 68 Ga-DOTATATE PET/CT and 123 I-MIBG SPECT/CT in the Imaging of Functional Pheochromocytoma in an Adolescent Patient With Von Hippel-Lindau Syndrome.
case_report · Level V
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- Record sourced from PubMed, PMID 38861407.
- Also identified by DOI 10.1097/RLU.0000000000005308.
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Abstract
A 17-year-old boy with Von Hippel-Lindau syndrome presented with hypertension, raised plasma catecholamines, and MRI findings of a new pancreatic tail lesion and 2 stable right adrenal lesions concerning for functional neuroendocrine tumors. A 68 Ga-DOTATATE PET/CT demonstrated intense tracer avidity within the pancreatic lesion with minimal uptake in the adrenal lesions. Conversely, a 123 I-MIBG SPECT/CT study demonstrated high-grade tracer uptake within the adrenal lesions, with no significant uptake appreciated in the pancreatic lesion. The adrenal lesions were resected, and pathology was consistent with pheochromocytoma. Plasma catecholamines returned to within the normal range and hypertension resolved.
Medical subject headings
- Pheochromocytoma
- Organometallic Compounds
- von Hippel-Lindau Disease
- Positron Emission Tomography Computed Tomography
- 3-Iodobenzylguanidine
- Adrenal Gland Neoplasms
- Single Photon Emission Computed Tomography Computed Tomography