H<sub>2</sub>Se-evolving bio-heterojunctions promote cutaneous regeneration in infected wounds by inhibiting excessive cellular senescence.
basic_science · Level V
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- Record sourced from PubMed, PMID 38861831.
- Also identified by DOI 10.1016/j.biomaterials.2024.122659.
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Abstract
Pathogenic infection leads to excessive senescent cell accumulation and stagnation of wound healing. To address these issues, we devise and develop a hydrogen selenide (H<sub>2</sub>Se)-evolving bio-heterojunction (bio-HJ) composed of graphene oxide (GO) and FeSe<sub>2</sub> to deracinate bacterial infection, suppress cellular senescence and remedy recalcitrant infected wounds. Excited by near-infrared (NIR) laser, the bio-HJ exerts desired photothermal and photodynamic effects, resulting in rapid disinfection. The crafted bio-HJ could also evolve gaseous H<sub>2</sub>Se to inhibit cellular senescence and dampen inflammation. Mechanism studies reveal the anti-senescence effects of H<sub>2</sub>Se-evolving bio-HJ are mediated by selenium pathway and glutathione peroxidase 1 (GPX1). More critically, in vivo experiments authenticate that the H<sub>2</sub>Se-evolving bio-HJ could inhibit cellular senescence and potentiate wound regeneration in rats. As envisioned, our work not only furnishes the novel gasotransmitter-delivering bio-HJ for chronic infected wounds, but also gets insight into the development of anti-senescence biomaterials.
Medical subject headings
- Cellular Senescence
- Wound Healing
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