Double-Stranded RNA to Mimic Viral Infection for Cancer Immunotherapy.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 38869441.
- Also identified by DOI 10.1158/1078-0432.CCR-24-0938.
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Abstract
The presence of moieties denoting viral infection is crucial to mount powerful cytotoxic T-cell immune responses acting through innate receptors such as Toll-like receptor 3. For cancer immunotherapy, several safe analogues of viral double-stranded RNA are under clinical development following compelling evidence for efficacy in mouse models. See related article by van Eijck et al., p. 3447.
Medical subject headings
- Neoplasms
- RNA, Double-Stranded
- Immunotherapy
- Virus Diseases