Flare Phenomenon After 177 Lu-DOTA-IBA Therapy in Bone Metastases of Lung Cancer.

Hua, Qingchu; Wang, Wei; Qu, Gengcuo; Pei, Wenjie; Chen, Yue · Clin Nucl Med · 2024

case_report · Level V

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Abstract

The flare phenomenon is a transient increase in the number or intensity of lesions on bone scans after treatment, signifying curative effect. DOTA-ibandronic acid (DOTA-IBA) is a new prodrug that targets bone metastases and can be labeled with 177 Lu. Here, we report the case of a 58-year-old woman with bone metastasis, in whom the flare phenomenon was observed after 4 cycles of 177 Lu-DOTA-IBA treatment. No adverse effects were observed during the treatment and follow-up periods.

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