Heterostructure Nanozyme with Hyperthermia-Amplified Enzyme-Like Activity and Controlled Silver Release for Synergistic Antibacterial Therapy.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 38900390.
- Also identified by DOI 10.1002/adhm.202401602.
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Abstract
Heterostructure nanozymes as antibiotic-free antimicrobial agents exhibit great potential for multidrug-resistant (MDR) bacterial strains elimination. However, realization of heterostructure antimicrobials with enhanced interfacial interaction for synergistically amplified antibacterial therapy is still a great challenge. Herein, oxygen-vacancy-enriched glucose modified MoO<sub>x</sub> (G-MoO<sub>x</sub>) is exploited as a reducing agent to spontaneously reduce Ag (I) into Ag (0) that in situ grows onto the surface of G-MoO<sub>x</sub>. The resultant Ag doped G-MoO<sub>x</sub> (Ag/G-MoO<sub>x</sub>) heterostructure displays augmenting photothermal effect and NIR-enhanced oxidase-like activity after introducing Ag nanoparticles. What's more, NIR hyperthermia accelerate Ag<sup>+</sup> ions release from Ag nanoparticles. Introduction of Ag greatly enhances antimicrobial activities of Ag/G-MoO<sub>x</sub> against MDR bacteria, especially the hybrid loading with 1 wt% Ag NPs exhibiting antibacterial efficacy up to 99.99% against Methicillin-resistant Staphylococcus aureus (MRSA, 1×10<sup>6</sup> CFU mL<sup>-1</sup>).
Medical subject headings
- Silver
- Anti-Bacterial Agents
- Metal Nanoparticles