Preventing MMP23-mediated cleavage of podocyte RARRES1: a novel strategy to halt chronic kidney disease progression?
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 38906649.
- Also identified by DOI 10.1016/j.kint.2024.05.004.
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Abstract
Glomerular issues and affected podocytes are at the origin of 80% of chronic kidney disease cases. Thus, acquiring a deeper understanding in this domain is necessary to halt progressive kidney damage. In this study, the authors investigated the harmful impact of podocyte-cleaved soluble retinoic acid receptor responder protein-1 on podocytes and proximal tubular cells and identified matrix metalloprotease 23 as the enzyme responsible for cleaving retinoic acid receptor responder protein-1. These findings provide new insights into chronic kidney disease progression, suggesting innovative treatment avenues.
Medical subject headings
- Podocytes
- Renal Insufficiency, Chronic
- Disease Progression