Use of an embolic protection device during carotid artery stenting is associated with lower periprocedural risk.

Abstract

To investigate associations between individual embolic protection device (EPD) use and respective center policy with periprocedural outcomes after carotid artery stenting (CAS). This analysis is based on the nationwide German statutory quality assurance database and was funded by Germany's Federal Joint Committee Innovation Fund (G-BA Innovationsfonds, 01VSF19016 ISAR-IQ). According to their policy towards EPD use, hospitals were categorized as <i>routine EPD</i> (>90%), <i>selective EPD</i> (10-90%), or <i>sporadic EPD</i> (<10%) <i>centers</i>. Primary study outcome was in-hospital stroke or death. Univariate and multivariate regression analyses were performed. Overall, 19 302 patients who had undergone CAS between 2013 and 2016 were included. The highest in-hospital stroke or death rate was found in <i>sporadic EPD</i> centers, followed by <i>selective</i> and <i>routine EPD</i> centers (3.1% vs 2.9% vs 1.8%; P<0.001). Across the whole cohort, EPD use was associated with a lower in-hospital stroke or death rate (OR=0.60; 95% CI 0.50 to 0.72). In the multivariate regression analysis, EPD use was independently associated with a lower in-hospital stroke rate (aOR=0.66; 95% CI 0.46 to 0.94). Regarding center policy, <i>routine EPD</i> centers showed a significantly lower in-hospital mortality compared with <i>sporadic EPD</i> centers (aOR=0.44; 95% CI 0.22 to 0.88). In a contemporary real-world cohort with low risk of selection bias, EPD use was associated with a lower in-hospital risk of stroke. A center policy of routine EPD use was associated with lower mortality. These data support routine use of EPD during CAS to enhance patient safety.