The multifaceted roles of mitochondria in osteoblasts: from energy production to mitochondrial-derived vesicle secretion.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 38907370.
- Also identified by DOI 10.1093/jbmr/zjae088 and PMC identifier 11371665.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
Mitochondria in osteoblasts have been demonstrated to play multiple crucial functions in bone formation from intracellular adenosine triphosphate production to extracellular secretion of mitochondrial components. The present review explores the current knowledge about mitochondrial biology in osteoblasts, including mitochondrial biogenesis, bioenergetics, oxidative stress generation, and dynamic changes in morphology. Special attention is given to recent findings, including mitochondrial donut formation in osteoblasts, which actively generates mitochondrial-derived vesicles (MDVs), followed by extracellular secretion of small mitochondria and MDVs. We also discuss the therapeutic effects of targeting osteoblast mitochondria, highlighting their potential applications in improving bone health.
Medical subject headings
- Osteoblasts
- Mitochondria
- Energy Metabolism