Strategies for the development of metalloimmunotherapies.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 38914800.
- Also identified by DOI 10.1038/s41551-024-01221-7 and PMC identifier 11410547.
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Abstract
Metal ions play crucial roles in the regulation of immune pathways. In fact, metallodrugs have a long record of accomplishment as effective treatments for a wide range of diseases. Here we argue that the modulation of interactions of metal ions with molecules and cells involved in the immune system forms the basis of a new class of immunotherapies. By examining how metal ions modulate the innate and adaptive immune systems, as well as host-microbiota interactions, we discuss strategies for the development of such metalloimmunotherapies for the treatment of cancer and other immune-related diseases.
Medical subject headings
- Immunotherapy
- Neoplasms