tracerDB: a crowdsourced fluorescent tracer database for target engagement analysis.
Where this comes from
- Record sourced from PubMed, PMID 38969708.
- Also identified by DOI 10.1038/s41467-024-49896-5 and PMC identifier 11226670.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
Investigating ligand-protein complexes is essential in the areas of chemical biology and drug discovery. However, detailed information on key reagents such as fluorescent tracers and associated data for the development of widely used bioluminescence resonance energy transfer (BRET) assays including NanoBRET, time-resolved Förster resonance energy transfer (TR-FRET) and fluorescence polarization (FP) assays are not easily accessible to the research community. We created tracerDB, a curated database of validated tracers. This resource provides an open access knowledge base and a unified system for tracer and assay validation. The database is freely available at https://www.tracerdb.org/ .
Medical subject headings
- Fluorescence Resonance Energy Transfer