Interpretation of Data from Translational Rodent Nerve Injury and Repair Models.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 38972687.
- Also identified by DOI 10.1016/j.hcl.2024.03.004 and PMC identifier 11228394.
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Abstract
This article highlights the use of rodents as preclinical models to evaluate the management of nerve injuries, describing the pitfalls and value from rodent nerve injury and regeneration outcomes, as well as treatments derived from these rodent models. The anatomic structure, size, and cellular and molecular differences and similarities between rodent and human nerves are summarized. Specific examples of success and failure when assessing outcome metrics are presented for context. Evidence for translation to clinical practice includes the topics of electrical stimulation, Tacrolimus (FK506), and acellular nerve allografts.
Medical subject headings
- Peripheral Nerve Injuries
- Nerve Regeneration
- Disease Models, Animal