Effect of Bioactive Black Phosphorus Nanomaterials on Cancer-Associated Fibroblast Heterogeneity in Pancreatic Cancer.
basic_science · Level V
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- Record sourced from PubMed, PMID 38975953.
- Also identified by DOI 10.1021/acsnano.4c06147.
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Abstract
Tumor-stromal interactions and stromal heterogeneity in the tumor microenvironment are critical factors that influence the progression, metastasis, and chemoresistance of pancreatic ductal adenocarcinoma (PDAC). Here, we used spatial transcriptome technology to profile the gene expression landscape of primary PDAC and liver metastatic PDAC after bioactive black phosphorus nanomaterial (bioactive BP) treatment using a murine model of PDAC (<i>LSL-Kras</i><sup><i>G12D</i>/+</sup>; <i>LSL-Trp53</i><sup><i>R172H</i>/+</sup>; and <i>Pdx-1-Cre</i> mice). Bioinformatic and biochemical analyses showed that bioactive BP contributes to the tumor-stromal interplay by suppressing cancer-associated fibroblast (CAF) activation. Our results showed that bioactive BP contributes to CAF heterogeneity by decreasing the amount of inflammatory CAFs and myofibroblastic CAFs, two CAF subpopulations. Our study demonstrates the influence of bioactive BP on tumor-stromal interactions and CAF heterogeneity and suggests bioactive BP as a potential PDAC treatment.
Medical subject headings
- Pancreatic Neoplasms
- Nanostructures
- Phosphorus
- Cancer-Associated Fibroblasts
- Carcinoma, Pancreatic Ductal