Reduction hits the sweet spot: A revised biosynthesis of dolichol.

O'Connor, Sarah E · Cell · 2024

editorial · Level V

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Abstract

Dolichol is a lipid that is involved in protein glycosylation, a process that is essential for all eukaryotic life. In this issue of Cell, Wilson and coworkers<sup>1</sup> report how a rare human genetic disorder led to the discovery of dolichol biosynthesis.

Medical subject headings