NETosis Impact on Tumor Biology, Radiation, and Systemic Therapy Resistance.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 39007757.
- Also identified by DOI 10.1158/1078-0432.CCR-24-1363 and PMC identifier 11398986.
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Abstract
Neutrophil extracellular trap (NET)osis via lytic neutrophil death or neutrophil activation is associated with standard cancer therapies, notably including radiotherapy; is immunosuppressive; and may enhance metastasis and treatment resistance. This emerging area of research should be prioritized in drug development and standard of care treatment paradigms including radiation therapy, chemotherapy, and immunotherapy. See related article by Teijeira et al., p. 4131.
Medical subject headings
- Neoplasms
- Extracellular Traps
- Drug Resistance, Neoplasm
- Neutrophils