Rab10-CAV1 mediated intraluminal vesicle transport to migrasomes.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 39008679.
- Also identified by DOI 10.1073/pnas.2319267121 and PMC identifier 11287133.
- Licence recorded as CC BY-NC-ND.
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Abstract
Migrasomes, vesicular organelles generated on the retraction fibers of migrating cells, play a crucial role in migracytosis, mediating intercellular communication. The cargoes determine the functional specificity of migrasomes. Migrasomes harbor numerous intraluminal vesicles, a pivotal component of their cargoes. The mechanism underlying the transportation of these intraluminal vesicles to the migrasomes remains enigmatic. In this study, we identified that Rab10 and Caveolin-1 (CAV1) mark the intraluminal vesicles in migrasomes. Transport of Rab10-CAV1 vesicles to migrasomes required the motor protein Myosin Va and adaptor proteins RILPL2. Notably, the phosphorylation of Rab10 by the kinase LRRK2 regulated this process. Moreover, CSF-1 can be transported to migrasomes through this mechanism, subsequently fostering monocyte-macrophage differentiation in skin wound healing, which served as a proof of the physiological importance of this transporting mechanism.
Medical subject headings
- rab GTP-Binding Proteins
- Caveolin 1
- Cell Movement