Seroepidemiology of hepatitis B virus (HBV) and relationship to serum transaminase levels in Indian population.
retrospective_cohort · Level III
Where this comes from
- Record sourced from PubMed, PMID 39027877.
- Also identified by DOI 10.4103/jfmpc.jfmpc_1746_23 and PMC identifier 11254088.
- Licence recorded as CC BY-NC-SA.
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Abstract
Hepatitis B virus (HBV) infection is a serious public health issue that must be addressed. The goal of this study was to investigate the correlation between serological status for hepatitis Be antigen (HBeAg)/anti-HBe, serum transaminase levels, and serum HBV-DNA in patients with chronic HBV infection. A retrospective observational study with 620 patients with persistent HBV infection (mean age, 36.35 years; 506 men) was conducted. All patients tested positive for hepatitis B surface antigen (HBsAg). Liver profile, HBeAg, and anti-HBe antibody tests were conducted for all patients. Additionally, serum HBV DNA was examined using a DNA assay in these individuals. Of 620 patients, 114 (18.39%) were HBeAg-positive and 506 (81.61%) HBeAg-negative. A detectable level of HBV DNA was found in 89.79% of HBeAg-positive/anti-HBe negative patients compared to HBeAg-negative/anti-HBe positive carriers 33.69% (<i>P</i> value <0.0001). The median viral load was significantly higher in HBeAg-positive cases (4.72 log10 copies/mL) than in HBeAg-negative individuals (4.23 log10 copies/mL; <i>P</i> = 0.997). Additionally, a higher proportion of HBeAg-positive samples (<i>P</i> = 0.0001) had HBV-DNA levels above 10,000 copies/mL.