DNA-binding protein-A: a multitool in tubular epithelial cells.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 39032963.
- Also identified by DOI 10.1016/j.kint.2024.05.022.
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Abstract
Acute kidney injury is still associated with high morbidity and mortality. Reichardt et al. investigated DNA-binding protein-A (Ybx3) in acute kidney injury induced by ischemia-reperfusion injury and found that mice lacking Ybx3 have altered mitochondrial function and increased antioxidant activity, making them more resistant to ischemia-reperfusion injury-acute kidney injury. The study highlights a new role of the multifaceted protein DNA-binding protein-A, which could be potentially therapeutically exploited.
Medical subject headings
- Acute Kidney Injury
- Epithelial Cells
- Kidney Tubules
- Reperfusion Injury