Acute kidney injury genetic risks: taking it 1 SNP at a time.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 39032964.
- Also identified by DOI 10.1016/j.kint.2024.05.011.
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Abstract
This commentary addresses some of the strengths, shortcomings, and challenges of the genome-wide association study of acute kidney injury (AKI) report in this issue. This AKI genome-wide association study is well executed and provides significant progress in finding 2 genome-wide significant loci. However, significant interpretive challenges remain, where advancements in methods are needed because of the clinical heterogeneity of the AKI phenotype, plus possible bias due to genetic correlation between index hospitalization risk and AKI risk.
Medical subject headings
- Acute Kidney Injury
- Genome-Wide Association Study
- Polymorphism, Single Nucleotide
- Genetic Predisposition to Disease