Levels of Angiopoietin 2 Are Predictive for Mortality in Patients Infected With Yellow Fever Virus.
case_control · Level III
Where this comes from
- Record sourced from PubMed, PMID 39052712.
- Also identified by DOI 10.1093/infdis/jiad389 and PMC identifier 11272082.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
In 2018 there was a large yellow fever outbreak in São Paulo, Brazil, with a high fatality rate. Yellow fever virus can cause, among other symptoms, hemorrhage and disseminated intravascular coagulation, indicating a role for endothelial cells in disease pathogenesis. Here, we conducted a case-control study and measured markers related to endothelial damage in plasma and its association with mortality. We found that angiopoietin 2 is strongly associated with a fatal outcome and could serve as a predictive marker for mortality. This could be used to monitor severe cases and provide care to improve disease outcome.
Medical subject headings
- Yellow Fever
- Angiopoietin-2
- Biomarkers
- Yellow fever virus