A metabolic balance of GLP-1 and NMDA receptors in the brain.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 39059361.
- Also identified by DOI 10.1016/j.cell.2024.06.031.
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Abstract
Glucagon-like peptide-1 (GLP-1) and N-methyl-D-aspartate (NMDA) receptors in the brain regulate metabolic homeostasis. In a paper published in Nature, Petersen et al. describe a bimodal molecule that conjugates a GLP-1 analog with MK-801 (NMDA receptor antagonist), which lowers feeding and body weight to a greater extent than the GLP-1R agonist alone.
Medical subject headings
- Receptors, N-Methyl-D-Aspartate
- Glucagon-Like Peptide 1
- Brain