"Boosting" tumor immunity in elderly mice by hyperactivating dendritic cells.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 39059365.
- Also identified by DOI 10.1016/j.cell.2024.06.025.
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Abstract
Immunosenescence poses a significant challenge to tumor immunotherapy in elderly individuals. In this issue of Cell, Zhivaki et al. elucidate that dendritic cells "hyperactivated" by specific adjuvants elicit T<sub>H</sub>1-skewed CD4<sup>+</sup> T cell responses in a manner contingent on the NLRP3 inflammasome, which can eliminate tumors in aged mice.
Medical subject headings
- Dendritic Cells