A conserved oomycete effector RxLR23 triggers plant defense responses by targeting ERD15La to release NbNAC68.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 39068146.
- Also identified by DOI 10.1038/s41467-024-50782-3 and PMC identifier 11283518.
- Licence recorded as CC BY-NC-ND.
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Abstract
Oomycete pathogens deliver many effectors to enhance virulence or suppress plant immunity. Plant immune networks are interconnected, in which a few effectors can trigger a strong defense response when recognized by immunity-related proteins. How effectors activate plant defense response remains poorly understood. Here we report Phytophthora capsici effector RxLR23<sup>KM</sup> can induce plant cell death and plant immunity. RxLR23<sup>KM</sup> specifically binds to ERD15La, a regulator of abscisic acid and salicylic acid pathway, and the binding intensity depends on the amino acid residues (K<sup>93</sup> and M<sup>320</sup>). NbNAC68, a downstream protein of ERD15La, can stimulate plant immunity that is compromised after binding with ERD15La. Silencing of NbNAC68 substantially prevents the activation of plant defense response. RxLR23<sup>KM</sup> binds to ERD15La, releasing NbNAC68 to activate plant immunity. These findings highlight a strategy of plant defense response that ERD15La as a central regulator coordinates RxLR23<sup>KM</sup> to regulate NbNAC68-triggered plant immunity.
Medical subject headings
- Phytophthora
- Plant Immunity
- Plant Diseases
- Arabidopsis