Ventilator-associated pneumonia: pathobiological heterogeneity and diagnostic challenges.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 39085269.
- Also identified by DOI 10.1038/s41467-024-50805-z and PMC identifier 11291905.
- Licence recorded as CC BY-NC-ND.
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Abstract
Ventilator-associated pneumonia (VAP) affects up to 20% of critically ill patients and induces significant antibiotic prescription pressure, accounting for half of all antibiotic use in the ICU. VAP significantly increases hospital length of stay and healthcare costs yet is also associated with long-term morbidity and mortality. The diagnosis of VAP continues to present challenges and pitfalls for the currently available clinical, radiological and microbiological diagnostic armamentarium. Biomarkers and artificial intelligence offer an innovative potential direction for ongoing future research. In this Review, we summarise the pathobiological heterogeneity and diagnostic challenges associated with VAP.
Medical subject headings
- Pneumonia, Ventilator-Associated