Dendritic Cell Plasticity, Radiation, and Newton's Third Law.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 39087954.
- Also identified by DOI 10.1158/1078-0432.CCR-24-1506 and PMC identifier 11446472.
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Abstract
Regulatory T cells protect damaged tissues but can undermine the effects of cancer treatments, including radiotherapy (RTx). Intratumoral immunostimulatory dendritic cells (type 1 conventional dendritic cells) respond to RTx with the production of regulatory T cell-attracting MDC/CCL22, undermining RTx effects. That effect can be reversed by EGFR-targeted IFNα, highlighting cDC1 plasticity and relevance as therapeutic targets. See related article by Bugno et al., p. 4450.
Medical subject headings
- Dendritic Cells
- Neoplasms
- Cell Plasticity