Ageing-related bone and immunity changes: insights into the complex interplay between the skeleton and the immune system.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 39103328.
- Also identified by DOI 10.1038/s41413-024-00346-4 and PMC identifier 11300832.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
Ageing as a natural irreversible process inherently results in the functional deterioration of numerous organ systems and tissues, including the skeletal and immune systems. Recent studies have elucidated the intricate bidirectional interactions between these two systems. In this review, we provide a comprehensive synthesis of molecular mechanisms of cell ageing. We further discuss how age-related skeletal changes influence the immune system and the consequent impact of immune system alterations on the skeletal system. Finally, we highlight the clinical implications of these findings and propose potential strategies to promote healthy ageing and reduce pathologic deterioration of both the skeletal and immune systems.
Medical subject headings
- Aging
- Immune System
- Bone and Bones