Lactylation: Linking the Warburg effect to DNA damage repair.
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- Record sourced from PubMed, PMID 39111282.
- Also identified by DOI 10.1016/j.cmet.2024.06.015.
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Abstract
In this issue of Cell Metabolism, Li et al. report that the highly expressed aldehyde dehydrogenase 1 family member A3 interacts with pyruvate kinase M2 (PKM2) in glioblastoma cells. Consequently, PKM2 tetramerization and activation promote lactate production, leading to the lactylation and nuclear translocation of XRCC1 for DNA damage repair and therapeutic resistance.
Medical subject headings
- DNA Damage
- DNA Repair