A pattern emerges in chromatin aging: AP-1 steals the show.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 39111283.
- Also identified by DOI 10.1016/j.cmet.2024.07.015.
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Abstract
During aging, transcriptional programs of cell identity are partially eroded, reducing cellular fitness and resilience. Patrick et al.<sup>1</sup> unveil a general mechanism for this process that consists of the progressive loss of transcription factor AP-1 from cell identity enhancers and its relocation by competition to stress-response elements.
Medical subject headings
- Transcription Factor AP-1
- Chromatin