Single Monoclonal Antibodies Should Not Be Used for COVID-19 Therapy: A Call for Antiviral Stewardship.

Casadevall, Arturo; Focosi, Daniele; Pirofski, Liise-Anne; Shoham, Shmuel · Clin Infect Dis · 2024

editorial · Level V

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Abstract

The COVID-19 pandemic witnessed the greatest deployment of monoclonal antibody (mAb) therapies for an infectious disease, but all were defeated by SARS-CoV-2 evolution. As new mAbs are developed, the infectious disease community needs stewardship practices to reduce emergence of resistance.

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