CD137 (4-1BB) and T-Lymphocyte Exhaustion.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 39120463.
- Also identified by DOI 10.1158/1078-0432.CCR-24-1568.
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Abstract
CD137 (4-1BB) costimulation results in the potent activation of antitumor T lymphocytes and elicits antitumor efficacy that is synergistic with anti-PD(L)1 checkpoint inhibitors, especially when using bispecific constructs. Emerging experimental evidence indicates that 4-1BB ligation prevents and may revert T-cell exhaustion. See related article by Jeon et al., p. 4155.
Medical subject headings
- Tumor Necrosis Factor Receptor Superfamily, Member 9
- Neoplasms
- T-Lymphocytes