Neural subspaces of imagined movements in parietal cortex remain stable over several years in humans.

Abstract

<i>Objective.</i>A crucial goal in brain-machine interfacing is the long-term stability of neural decoding performance, ideally without regular retraining. Long-term stability has only been previously demonstrated in non-human primate experiments and only in primary sensorimotor cortices. Here we extend previous methods to determine long-term stability in humans by identifying and aligning low-dimensional structures in neural data.<i>Approach.</i>Over a period of 1106 and 871 d respectively, two participants completed an imagined center-out reaching task. The longitudinal accuracy between all day pairs was assessed by latent subspace alignment using principal components analysis and canonical correlations analysis of multi-unit intracortical recordings in different brain regions (Brodmann Area 5, Anterior Intraparietal Area and the junction of the postcentral and intraparietal sulcus).<i>Main results.</i>We show the long-term stable representation of neural activity in subspaces of intracortical recordings from higher-order association areas in humans.<i>Significance.</i>These results can be practically applied to significantly expand the longevity and generalizability of brain-computer interfaces.Clinical TrialsNCT01849822, NCT01958086, NCT01964261.