Lacosamide and Levetiracetam Are Not Toxic to the Developing Mouse Brain.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 39136212.
- Also identified by DOI 10.1002/ana.27052.
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Abstract
Many antiseizure medications cause apoptotic cell death in developing brains. The newer antiseizure medication lacosamide is increasingly used in neonates and infants. Neurotoxicity of lacosamide and its combination with levetiracetam was studied in neonatal mice. Animals received single or repeat injections of saline, phenobarbital (75mg/kg), lacosamide (20-40mg/kg), levetiracetam (100mg/kg), lacosamide (40mg/kg) + levetiracetam (100mg/kg) and euthanized at 6 to 30 hours. Cells undergoing apoptosis were increased in the brains of phenobarbital-treated animals. Densities of apoptotic profiles following lacosamide and levetiracetam treatment did not differ from saline-treated controls. Findings suggest that lacosamide, levetiracetam and their combination do not cause apoptosis in developing mouse brains. ANN NEUROL 2024;96:812-818.
Medical subject headings
- Levetiracetam
- Lacosamide
- Anticonvulsants
- Brain
- Acetamides
- Animals, Newborn
- Piracetam