Expression of Kielin/chordin-like protein is regulated by BMP-2 in osteoblasts.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 39139593.
- Also identified by DOI 10.1016/j.bonr.2024.101793 and PMC identifier 11321374.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
Bone morphogenetic protein (BMP), an osteoinductive factor, is a cytokine that induces osteoblast differentiation and mineralization, and expected to be applicable for hard tissue reconstruction. Kielin/chordin-like protein (Kcp), a member of the family of cysteine-rich proteins, enhances BMP signaling. The present study found that expression of <i>Kcp</i> in osteoblasts was induced by BMP-2 in a concentration- and time-dependent manner. Up-regulation of <i>Kcp</i> by BMP-2 was inhibited by Dorsomorphin, a SMAD signaling inhibitor. The involvement of up-regulation of <i>Kcp</i> by BMP-2 in induction of osteoblast differentiation by BMP-2 was also examined, which showed that suppression of <i>Kcp</i> expression by si <i>Kcp</i> partially inhibited induction of osteoblast differentiation and mineralization by BMP-2. Together, these results suggest that <i>Kcp</i> induced by BMP-2 functions to provide positive feedback for promotion of osteoblastic differentiation and mineralization by BMP-2 in osteoblasts.