Blood-brain barrier dysfunction in aging is mediated by brain endothelial senescence.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 39143890.
- Also identified by DOI 10.1111/acel.14270 and PMC identifier 11488312.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
BBB dysfunction during aging is characterized by an increase in its permeability and phenotypic alterations of brain endothelial cells (BECs) including dysregulation of tight junction's expression. Here we have investigated the role of BEC senescence in the dysfunction of the BBB. Our results suggest that the transition from young to aged BBB is mediated, at least in part by BEC senescence.
Medical subject headings
- Blood-Brain Barrier
- Cellular Senescence
- Aging
- Endothelial Cells