What makes the kidney so tolerant?
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 39145458.
- Also identified by DOI 10.1172/JCI183501 and PMC identifier 11324287.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
Various organ allografts differ in their propensity to be spontaneously accepted without any immunosuppressive treatment. Understanding the mechanisms behind these differences can aid in managing alloimmune responses in general. C57BL/6 mice naturally accept DBA/2J kidney allografts, forming tertiary lymphoid organs containing regulatory T cells (rTLOs), crucial for graft acceptance. In this issue of the JCI, Yokose and colleagues revealed that rTLOs promote conversion of cytotoxic alloreactive CD8+ T cells into exhausted/regulatory ones, through an IFN-γ-mediated mechanism. Their study provides insights into tolerance development that could help promote the acceptance of grafts at higher risk of rejection.
Medical subject headings
- Kidney Transplantation
- T-Lymphocytes, Regulatory
- CD8-Positive T-Lymphocytes
- Interferon-gamma