A core proteome profile unites mouse models and patients in Alzheimer disease.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 39168096.
- Also identified by DOI 10.1016/j.xcrm.2024.101683 and PMC identifier 11384129.
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Abstract
Levites et al. demonstrate that mouse models of Alzheimer disease (AD), exhibiting amyloid-beta (Αβ) plaque formation, share Αβ responsome proteins with humans. Their work underscores the value of these models in studying Αβ aggregation, cellular vulnerability, and early-stage AD pathology.
Medical subject headings
- Alzheimer Disease
- Disease Models, Animal
- Proteome