Aging kidneys reveal underlying mechanisms of endothelial dysfunction.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 39174195.
- Also identified by DOI 10.1016/j.kint.2024.06.020 and PMC identifier 11670792.
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Abstract
Jiang et al. show that zinc finger FYVE-type containing 21, a Rab5 effector in glomerular endothelial cells is involved in the maintenance of glomerular filtration barrier homeostasis through the stabilization of activated endothelial nitric oxide synthase on subcellular vesicles. The study demonstrates that zinc finger FYVE-type containing 21 could modulate the levels of caveolin-1 in glomerular endothelial cells using vesicle-based trafficking, thereby supporting endothelial nitric oxide synthase activity. The authors provide evidence that decreased zinc finger FYVE-type containing 21 expression in glomerular endothelial cells could play a role in aging-related glomerular filtration barrier dysfunction.
Medical subject headings
- Aging
- Nitric Oxide Synthase Type III
- Caveolin 1
- Endothelial Cells