In vitro human cell-based models: What can they do and what are their limitations?

Lutolf, Matthias P; Radisic, Milica; Beekman, Jeffrey; Huh, Dan Dongeun; Huch, Meritxell; Turco, Margherita Yayoi; Tahmasebi Birgani, Zeinab Niloofar; Gao, Dong et al. · Cell · 2024

basic_science · Level V

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Abstract

It is said that all models are wrong, but some are useful. In vitro human cell-based models are a prime example of this maxim. We asked researchers: when is your model system useful? How can it be made more useful? What are its limitations?

Medical subject headings