Impact of probiotics on gut microbiome of extremely preterm or extremely low birthweight infants.
meta_analysis · Level I
Where this comes from
- Record sourced from PubMed, PMID 39183307.
- Also identified by DOI 10.1038/s41390-024-03520-w and PMC identifier 12015168.
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Abstract
Meta-analysis of probiotic administration to very preterm or very low birthweight (VP/VLBW) infants shows reduced risk of necrotising enterocolitis (NEC). Separately reported outcomes for extremely preterm infants (<28 weeks) or extremely low birth weight infants (<1000 g) (EP/ELBW) are lacking meaning some clinicians do not administer probiotics to EP/ELBW infants despite their high risk of NEC. We present data showing the gut microbiome is impacted in EP/ELBW infants in a similar manner to VP/VLBW infants, suggesting that risk reduction for necrotising enterocolitis that is microbiome driven will also be seen in EP/ELBW infants, making probiotic administration beneficial.
Medical subject headings
- Enterocolitis, Necrotizing
- Gastrointestinal Microbiome
- Infant, Extremely Low Birth Weight
- Infant, Extremely Premature
- Probiotics