The epigenetic mechanism of metabolic risk in bipolar disorder.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 39188090.
- Also identified by DOI 10.1111/obr.13816.
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Abstract
Bipolar disorder (BD) is a complex and severe mental illness that causes significant suffering to patients. In addition to the burden of depressive and manic symptoms, patients with BD are at an increased risk for metabolic syndrome (MetS). MetS includes factors associated with an increased risk of atherosclerotic cardiovascular disease (CVD) and type 2 diabetes mellitus (T2DM), which may increase the mortality rate of patients with BD. Several studies have suggested a link between BD and MetS, which may be explained at an epigenetic level. We have focused on epigenetic mechanisms to review the causes of metabolic risk in BD.
Medical subject headings
- Bipolar Disorder
- Epigenesis, Genetic
- Metabolic Syndrome