Photodynamic therapy reduces the burden of small ultraviolet-induced epidermal clones in human and mouse skin.
case_series · Level IV
Where this comes from
- Record sourced from PubMed, PMID 39189591.
- Also identified by DOI 10.1093/bjd/ljae314 and PMC identifier 11570346.
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Abstract
Actinic keratoses (AKs) and keratinocyte carcinomas (KCs) arise from prolonged UV exposure, with precursor UV-induced clonal mutations (CMs) appearing in sun-damaged skin. Photodynamic therapy (PDT) is a common field treatment for AKs and early KCs, but its impact on subclinical CMs is unknown. This study examines CMs using targeted ultra-deep sequencing on epidermal samples. By comparing skin before and after PDT in five patients and a mouse model of chronic UV carcinogenesis, a significant reduction in low-frequency mutations post-treatment was revealed. These findings highlight PDT’s potential in modifying subclinical damage and propose low-variant allele frequency CMs as biomarkers for field treatment efficacy.