Endoscopic Response Reduces the Risk of Subsequent Pouchitis in Patients With Crohn's Disease-Like Pouch Inflammation.

Kayal, Maia; Posner, Hannah; Jimenez, Darwin; Huang, Justin; Dubinsky, Marla C; Colombel, Jean Frederic · Am J Gastroenterol · 2025

retrospective_cohort · Level III

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Abstract

The aim of this study was to report the frequency and impact of endoscopic response and remission on the risk of subsequent pouchitis in patients with Crohn's disease-like pouch inflammation (CDLPI) on therapy. This was a single-center retrospective study of patients older than 18 years with CDLPI on therapy. Among 110 included patients with CDLPI in clinical remission, endoscopic remission was not significantly associated with a reduced risk of subsequent pouchitis when compared with endoscopic response. Endoscopic response, not remission, is sufficient to reduce the risk of subsequent pouchitis in patients with CDLPI.

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