Integration of mass cytometry and mass spectrometry imaging for spatially resolved single-cell metabolic profiling.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 39210066.
- Also identified by DOI 10.1038/s41592-024-02392-6 and PMC identifier 11466816.
- Licence recorded as CC BY-NC-ND.
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Abstract
The integration of spatial omics technologies can provide important insights into the biology of tissues. Here we combined mass spectrometry imaging-based metabolomics and imaging mass cytometry-based immunophenotyping on a single tissue section to reveal metabolic heterogeneity at single-cell resolution within tissues and its association with specific cell populations such as cancer cells or immune cells. This approach has the potential to greatly increase our understanding of tissue-level interplay between metabolic processes and their cellular components.
Medical subject headings
- Single-Cell Analysis
- Metabolomics