Clinical Application of Phage Immunoprecipitation Sequencing to Diagnose Enterovirus D68 as the Underlying Etiology in a Case of Guillain-Barré Syndrome.

Li, Fang Fang; Faber, Alison; Caleta, Jessica M; Goldfarb, David M; Sekirov, Inna; Prystajecky, Natalie A; Srigley, Jocelyn A; Mishaal, Ram et al. · J Infect Dis · 2025

case_report · Level V

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Abstract

Guillain-Barré syndrome (GBS) is an acute peripheral neuropathy often preceded by respiratory or gastrointestinal infections, though molecular testing of cerebrospinal fluid is often inconclusive. In a recent case of severe pediatric GBS in British Columbia, Canada, we detected cerebrospinal fluid antibodies against enterovirus D to link GBS with prior enterovirus D68 respiratory infection.

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