Neurovascular coupling during hypercapnia in cerebral blood flow regulation.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 39223137.
- Also identified by DOI 10.1038/s41467-024-50165-8 and PMC identifier 11368962.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
Neuronal activity consumes cellular energy and generates carbon dioxide (CO<sub>2</sub>). To counter this metabolic challenge, synaptic signalling communicates with nearby microvasculature to increase local blood flow. Is this process solely based on feedforward synaptic signalling, or is the generated CO<sub>2</sub> also involved? This question was addressed in mice in a new Nature Communications publication by Tournissac and colleagues where they showed that neurovascular coupling is not affected by exogenous CO<sub>2</sub> or its associated acidification.
Medical subject headings
- Hypercapnia
- Cerebrovascular Circulation
- Neurovascular Coupling