AI-integrated Screening to Replace Double Reading of Mammograms: A Population-wide Accuracy and Feasibility Study.
retrospective_cohort · Level III
Where this comes from
- Record sourced from PubMed, PMID 39230423.
- Also identified by DOI 10.1148/ryai.230529 and PMC identifier 11605135.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
Mammography screening supported by deep learning-based artificial intelligence (AI) solutions can potentially reduce workload without compromising breast cancer detection accuracy, but the site of deployment in the workflow might be crucial. This retrospective study compared three simulated AI-integrated screening scenarios with standard double reading with arbitration in a sample of 249 402 mammograms from a representative screening population. A commercial AI system replaced the first reader (scenario 1: integrated AI<sub>first</sub>), the second reader (scenario 2: integrated AI<sub>second</sub>), or both readers for triaging of low- and high-risk cases (scenario 3: integrated AI<sub>triage</sub>). AI threshold values were chosen based partly on previous validation and setting the screen-read volume reduction at approximately 50% across scenarios. Detection accuracy measures were calculated. Compared with standard double reading, integrated AI<sub>first</sub> showed no evidence of a difference in accuracy metrics except for a higher arbitration rate (+0.99%, <i>P</i> < .001). Integrated AI<sub>second</sub> had lower sensitivity (-1.58%, <i>P</i> < .001), negative predictive value (NPV) (-0.01%, <i>P</i> < .001), and recall rate (-0.06%, <i>P</i> = .04) but a higher positive predictive value (PPV) (+0.03%, <i>P</i> < .001) and arbitration rate (+1.22%, <i>P</i> < .001). Integrated AI<sub>triage</sub> achieved higher sensitivity (+1.33%, <i>P</i> < .001), PPV (+0.36%, <i>P</i> = .03), and NPV (+0.01%, <i>P</i> < .001) but lower arbitration rate (-0.88%, <i>P</i> < .001). Replacing one or both readers with AI seems feasible; however, the site of application in the workflow can have clinically relevant effects on accuracy and workload. <b>Keywords:</b> Mammography, Breast, Neoplasms-Primary, Screening, Epidemiology, Diagnosis, Convolutional Neural Network (CNN) <i>Supplemental material is available for this article.</i> Published under a CC BY 4.0 license.
Medical subject headings
- Mammography
- Breast Neoplasms
- Feasibility Studies