Precision adjuvants for pediatric vaccines.

Singh, Anjali; Boggiano, César; Yin, Dwight E; Polakowski, Laura; Majji, Sai P; Leitner, Wolfgang W; Levy, Ofer; De Paris, Kristina · Sci Transl Med · 2024

review · Level V

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Abstract

Elucidating optimal vaccine adjuvants for harnessing age-specific immune pathways to enhance magnitude, breadth, and durability of immunogenicity remains a key gap area in pediatric vaccine design. A better understanding of age-specific adjuvants will inform precision discovery and development of safe and effective vaccines for protecting children from preventable infectious diseases.

Medical subject headings