Defying "IL-11ness" by inhibiting inflammation: Strategy for health and longevity.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 39232279.
- Also identified by DOI 10.1016/j.cmet.2024.08.003.
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Abstract
Organismal aging involves several hallmark pathways, including chronic inflammation and metabolic dysfunction. However, the origin of age-related inflammation is incompletely understood. In a recent study published in Nature,<sup>1</sup> Widjaja et al. show that blocking the age-related increase in IL-11 restores immune-metabolic homeostasis and extends healthspan and lifespan in mice.
Medical subject headings
- Longevity
- Inflammation
- Interleukin-11