Determinants of Post-COVID Ill-Health in a Cohort of Canadian Healthcare Workers.

Zadunayski, Tanis; Durand-Moreau, Quentin; Adisesh, Anil; Burstyn, Igor; Labrèche, France; Ruzycki, Shannon; Cherry, Nicola · J Occup Environ Med · 2025

prospective_cohort · Level II

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Abstract

We aimed to estimate prevalence of post-COVID conditions (PCCs) among healthcare workers (HCWs) and to identify predisposing factors. A cohort of Canadian HCWs completed four questionnaires during the pandemic. At the final questionnaire, HCWs reported conditions attributed to earlier COVID-19. The proportion developing a PCC was estimated. Risk factors were evaluated by logistic regression. Among 4964 HCWs, 995 had one positive COVID test >90 days before completing the final questionnaire. A total of 266 (27%) developed a PCC. Factors predisposing HCWs to a PCC included depression and increased alcohol consumption reported preinfection, chronic ill-health prepandemic, and a perception that the infection was work-related. PCCs were less likely following vaccination. Most HCWs (98%) returned to work within 30 days, with 8% reporting severe PCC (n = 80). Predisposing factors reflected poor health preinfection. Most conditions were mild.

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